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Exploring Integrated Value of Influence (IVI)score in Colorectal Cancer PPI Network
Understanding the complex interplay between proteins is pivotal for unraveling the secrets of cellular functions and disease mechanisms. This blog post delves into the realm of Protein-Protein Interaction (PPI) networks, spotlighting the Integrated Value of Influence (IVI) as a metric for identifying key proteins within the networks. Unlike traditional centrality measures that offer a one-dimensional view, IVI amalgamates local, semi-local, and global network properties, providing a holistic and nuanced perspective of a nodes influence. Here I show how IVI integrates degree centrality, betweenness centrality, and other network metrics to pinpoint influential proteins. Moreover, this post will guide you through a hands-on example, employing network analysis tools and libraries to compute the IVI scores, there by unraveling the backbone of the PPI network. Whether you’re a bioinformatician, a researcher in computational biology, or social network or simply an enthusiast intrigued by the complexities of networks, this post will equip you with the knowledge and tools to harness the power of IVI .
Before we begin, this post is heavily influenced by this paper where they discuss about IVI scores .
I assume many readers are already aware of the centrality measures , but let's revisit…
